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Fig. 2 | Molecular Medicine

Fig. 2

From: lncRNA SNHG1 induced by SP1 regulates bone remodeling and angiogenesis via sponging miR-181c-5p and modulating SFRP1/Wnt signaling pathway

Fig. 2

LncRNA SNHG1 served as a sponge for miR-181c-5p. A starBase analysis showed the potential binding sites for SNHG1 and miR-181c-5p. B The BMSCs were transfected with miR-181c-5p mimics, miR-181c-5p inhibitor or their negative controls for 48 h, then the level of miR-181c-5p was measured suing qPCR. C The RIP assay performed to determine the interaction between SNHG1 and miR-181c-5p in BMSCs. D Luc-SNHG1-WT or Luc-SNHG1-MUT plasmids were co-transfected with miR-181c-5p mimics or negative control for 24 h, the luciferase activities in each group were measured. E The BMSCs were transfected with sh-SNHG1 or sh-NC, then the relative levels of SNHG1 and miR-181c-5p were measured through qPCR. **P < 0.01, ***P < 0.001

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Molecular Medicine

ISSN: 1528-3658