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Fig. 3 | Molecular Medicine

Fig. 3

From: Global identification of circular RNAs in imatinib (IM) resistance of chronic myeloid leukemia (CML) by modulating signaling pathways of circ_0080145/miR-203/ABL1 and circ 0051886/miR-637/ABL1

Fig. 3

The molecular relationships between circ_0080145, miR-203 and ABL1, as well as circ 005188, miR-637 and ABL1, were established via sequence analysis and luciferase assays (*P value < 0.05 vs. Control group). A A potential binding site of miR-203 was found on circ_0080145; B Luciferase assay validated that circ_0080145 targeted miR-203; C A potential binding site of miR-637 was found on circ 0051886; D Luciferase assay validated that circ_0051886 targeted miR-637; E A putative binding site of miR-203 was observed on the 3ʹUTR of ABL1 mRNA; F Luciferase assay validated that ABL1 mRNA was a target of miR-203; G A putative binding site of miR-637 was observed on the 3ʹUTR of ABL1 mRNA; H Luciferase assay validated that ABL1 mRNA was a target of miR-637

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Molecular Medicine

ISSN: 1528-3658