Fig. 1

ORN model mice exhibited increased renal lipid deposition and kidney injury. A–I Body weights (A), kidney weight/body weight ratios (B), blood glucose levels (C), TG levels (D), serum cholesterol levels (E), serum creatine levels (F), urinary microalbumin levels (G), BUN levels (H), and KIM-1 and NGAL levels (I) of ORN model mice compared to control mice. J Kidney sections stained with HE, PAS and Oil Red O trichrome. ORN, obesity-related nephropathy; TG, triglyceride; BUN, blood urea nitrogen; KIM-1, kidney injury molecule-1; NGAL, neutrophil gelatinase-associated lipocalin; HE, haematoxylin and eosin; PAS, periodic acid-Schiff. Significance was assessed by a Student's t test. The experimental data are shown as the mean ± SD. N = 10. *P < 0.05, **P < 0.01, ***P < 0.001