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Fig. 5 | Molecular Medicine

Fig. 5

From: LncRNA HCG18 upregulates TRAF4/TRAF5 to facilitate proliferation, migration and EMT of epithelial ovarian cancer by targeting miR-29a/b

Fig. 5

TRAF4/5 overexpression antagonizes the effect of HCG18 knockdown in EOC cells. A, B TRAF4/5 overexpression recovered the EOC cell proliferation inhibition effect of HCG18 knockdown, as determined by MTT and colony formation assays. C Effect of TRAF4/5 overexpression and HCG18 knockdown on EOC cell invasion as determined by Transwell assay. D Effect of TRAF4/5 overexpression and HCG18 knockdown on expression levels of EMT markers and transcription factors as detected by Western blot. E Effect of TRAF4/5 overexpression and HCG18 knockdown on cytokines as determined by qRT–PCR. F Effect of TRAF4/5 overexpression and HCG18 knockdown on the NF-κB and AKT signalling pathways by Western blot. n = 3. *P < 0.05, **P < 0.01, ***P < 0.001

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Molecular Medicine

ISSN: 1528-3658