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Table 1 Functional characterization of XIST in digestive system tumors

From: Long non-coding RNA XIST: a novel oncogene in multiple cancers

Tumor types Expression Role Function role miRNAs Related genes References
Esophageal cancer Upregulation Oncogene Proliferation, migration, and invasion miR-101 EZH2 Wu et al. 2017a)
Esophageal cancer Upregulation Oncogene Proliferation, apoptosis, migration, and invasion miR-494 CDK6/JAK2/STAT3 Chen et al. 2019a)
Esophageal cancer Upregulation Oncogene Cell cycle, proliferation, migration, invasion, and apoptosis miR-129-5p CCND1 Wang et al. 2021)
Gastric cancer Upregulation Oncogene Proliferation, migration, and invasion miR-101 EZH2 Chen et al. 2016)
Gastric cancer Upregulation Oncogene Proliferation and invasion miR-497 MACC1 Ma et al. 2017)
Gastric cancer Upregulation Oncogene Proliferation, migration, and invasion miR-185 TGF-β1 Zhang et al. 2018)
Gastric cancer Upregulation Oncogene Proliferation, migration, and invasion miR-337 JAK2 Zheng et al. 2020a)
Gastric cancer Upregulation Oncogene Proliferation, migration, and apoptosis miR-132 PXN Li et al. 2020b)
Colorectal cancer Upregulation Oncogene Proliferation miR-132-3p MAPK1 Song et al. 2017)
Colorectal cancer Upregulation Oncogene Proliferation, migration, invasion, emt, and stem cell formation miR-200b-3p ZEB1 Chen et al. 2017)
Colorectal cancer Upregulation Oncogene Migration and invasion miR-137 EZH2 Liu et al. 2018)
Colorectal cancer Upregulation Oncogene Proliferation and invasion miR-34a WNT1 Sun et al. 2018b)
Colorectal cancer Upregulation Oncogene Growth, viability, apoptosis, and emt miR-486b-5p NRP-2 Liu et al. 2019)
Colorectal cancer Upregulation Oncogene Migration, proliferation, emt, and apoptosis miR-93-5p HIF-1A Yang et al. 2020)
Colorectal cancer Upregulation Oncogene Proliferation, migration, invasion, and apoptosis miR-338-3p PAX5 Li et al. 2021)
Colorectal cancer Upregulation Oncogene Proliferation, migration, invasion, and apoptosis miR-497-5p FOXK1 Wang et al. 2020b)
Colorectal cancer Upregulation Oncogene Chemoresistance miR-124 SGK1 Zhu et al. 2018b)
Colorectal cancer Upregulation Oncogene Viability, proliferation, apoptosis, and chemoresistance miR-30a-5p ROR1 Zhang et al. 2019c)
Colorectal cancer Upregulation Oncogene Proliferation, migration, invasion, and chemoresistance miR-137 PKM2/PKM1 Zheng et al. 2020)
Pancreatic cancer Upregulation Oncogene Proliferation, migration, and invasion miR-34a-5p / Sun et al. 2018a)
Pancreatic cancer Upregulation Oncogene Proliferation miR-133a EGFR Wei et al. 2017)
Pancreatic cancer Upregulation Oncogene Proliferation miR-140/124 iASPP Liang et al. 2017)
Pancreatic cancer Upregulation Oncogene Emt miR-34a YAP Zou et al. 2020)
Pancreatic cancer Upregulation Oncogene Migration, invasion, and emt miR-429 ZEB1 Shen et al. 2019)
Pancreatic cancer Upregulation Oncogene Proliferation, migration, and invasion miR-141-3p TGF-β2 Sun and Zhang 2019)
Pancreatic cancer Upregulation Oncogene Proliferation miR-137 Notch1 Liu et al. 2020)
Hepatocellular carcinoma Upregulation Oncogene Proliferation miR-200b-3p / Liu and Xu 2019)
Hepatocellular carcinoma Upregulation Oncogene Proliferation and apoptosis miR-488 / Dong et al. 2020)
Hepatocellular carcinoma Upregulation Oncogene Proliferation and apoptosis miR-139-5p PDK1 Mo et al. 2017)
Hepatocellular carcinoma Upregulation Oncogene Proliferation, migration, and invasion miR-194-5p MAPK1 Kong et al. 2018)