Table 3 Functional characterization of XIST in respiratory system tumors
From: Long non-coding RNA XIST: a novel oncogene in multiple cancers
Tumor types | Expression | Role | Function role | miRNAs | Related genes | References |
|---|---|---|---|---|---|---|
Laryngeal cancer | Upregulation | Oncogene | Proliferation, migration, and invasion | miR-124 | EZH2 | Xiao et al. 2019) |
Laryngeal cancer | Upregulation | Oncogene | Proliferation, migration, invasion, and apoptosis | miR-144 | IRS1 | Cui et al. 2020) |
Laryngeal cancer | Upregulation | Oncogene | Proliferation, migration, invasion, and apoptosis | miR-125b-5p | TRIB2 | Liu et al. 2020) |
Lung cancer | Upregulation | Oncogene | Proliferation, invasion, and apoptosis | miR-186-5p | / | Wang et al. 2017b) |
Lung cancer | Upregulation | Oncogene | Proliferation, migration, invasion, and apoptosis | miR-449a | BCL2 | Zhang et al. 2017b) |
Lung cancer | Upregulation | Oncogene | Proliferation and apoptosis | miR-140 | iASPP | Tang et al. 2017) |
Lung cancer | Upregulation | Oncogene | Growth and motility | miR-374a | LARP1 | Xu et al. 2017) |
Lung cancer | Upregulation | Oncogene | Proliferation and emt | miR-137 | Notch1 | Wang et al. 2018) |
Lung cancer | Upregulation | Oncogene | Proliferation and invasion | miR-744 | RING1 | Wang et al. 2019) |
Lung cancer | Upregulation | Oncogene | Proliferation and apoptosis | miR-335 | SOD2 | Liu et al. 2019) |
Lung cancer | Upregulation | Oncogene | Proliferation, migration, and cell cycle | miR-16 | CDK8 | Zhou et al. 2019) |
Lung cancer | Upregulation | Oncogene | Proliferation, migration, invasion, and emt | miR-212-3p | CBLL1 | Qiu et al. 2019) |
Lung cancer | Upregulation | Oncogene | Proliferation, migration, invasion, and apoptosis | miR-363-3p | MDM2 | Rong et al. 2020) |
Lung cancer | Upregulation | Oncogene | Proliferation, migration, invasion, and apoptosis | miR-142-5p | PAX6 | Jiang et al. 2020) |
Lung cancer | Upregulation | Oncogene | Chemoresistance | let-7i | BAG-1 | Sun et al. 2017) |
Lung cancer | Upregulation | Oncogene | Autophagy and chemoresistance | miR-17 | ATG7 | Sun et al. 2017) |
Lung cancer | Upregulation | Oncogene | Proliferation, migration, apoptosis, and chemoresistance | miR-144-3p | MDR1 | Tian et al. 2019) |