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Table 3 Functional characterization of XIST in respiratory system tumors

From: Long non-coding RNA XIST: a novel oncogene in multiple cancers

Tumor types Expression Role Function role miRNAs Related genes References
Laryngeal cancer Upregulation Oncogene Proliferation, migration, and invasion miR-124 EZH2 Xiao et al. 2019)
Laryngeal cancer Upregulation Oncogene Proliferation, migration, invasion, and apoptosis miR-144 IRS1 Cui et al. 2020)
Laryngeal cancer Upregulation Oncogene Proliferation, migration, invasion, and apoptosis miR-125b-5p TRIB2 Liu et al. 2020)
Lung cancer Upregulation Oncogene Proliferation, invasion, and apoptosis miR-186-5p / Wang et al. 2017b)
Lung cancer Upregulation Oncogene Proliferation, migration, invasion, and apoptosis miR-449a BCL2 Zhang et al. 2017b)
Lung cancer Upregulation Oncogene Proliferation and apoptosis miR-140 iASPP Tang et al. 2017)
Lung cancer Upregulation Oncogene Growth and motility miR-374a LARP1 Xu et al. 2017)
Lung cancer Upregulation Oncogene Proliferation and emt miR-137 Notch1 Wang et al. 2018)
Lung cancer Upregulation Oncogene Proliferation and invasion miR-744 RING1 Wang et al. 2019)
Lung cancer Upregulation Oncogene Proliferation and apoptosis miR-335 SOD2 Liu et al. 2019)
Lung cancer Upregulation Oncogene Proliferation, migration, and cell cycle miR-16 CDK8 Zhou et al. 2019)
Lung cancer Upregulation Oncogene Proliferation, migration, invasion, and emt miR-212-3p CBLL1 Qiu et al. 2019)
Lung cancer Upregulation Oncogene Proliferation, migration, invasion, and apoptosis miR-363-3p MDM2 Rong et al. 2020)
Lung cancer Upregulation Oncogene Proliferation, migration, invasion, and apoptosis miR-142-5p PAX6 Jiang et al. 2020)
Lung cancer Upregulation Oncogene Chemoresistance let-7i BAG-1 Sun et al. 2017)
Lung cancer Upregulation Oncogene Autophagy and chemoresistance miR-17 ATG7 Sun et al. 2017)
Lung cancer Upregulation Oncogene Proliferation, migration, apoptosis, and chemoresistance miR-144-3p MDR1 Tian et al. 2019)