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Fig. 6 | Molecular Medicine

Fig. 6

From: Ketogenic diet ameliorates lipid dysregulation in type 2 diabetic mice by downregulating hepatic pescadillo 1

Fig. 6

β-HB reduced PES1 binding to the p300 promoter and downregulated PES-1 mediated acetylation of SREBP1c. a β-HB decreased PES1 binding to the p300 promoter. b, c PES1 knockdown or overexpression inhibited or enhanced the interaction between p300 and SREBP1c in hepatocytes. d β-HB treatment decreased the acetylation of SREBP1c in hepatocytes. e Pes1 knockout impaired the interaction between p300 and SREBP1c in mice. f KD feeding decreased the acetylation of SREBP1c in normal and diabetic mice. Data were shown as mean ± SEM for each experiment performed independently 3 times. *P < 0.05, **P < 0.01, ***P < 0.001 compared with control (ANOVA, Student–Newman–Keuls q test)

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Molecular Medicine

ISSN: 1528-3658