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Fig. 7 | Molecular Medicine

Fig. 7

From: Dendritic cell-mediated chronic low-grade inflammation is regulated by the RAGE-TLR4-PKCβ1 signaling pathway in diabetic atherosclerosis

Fig. 7

RAGE-TLR4-pPKCβ1 signal pathway diagram. After AGEs was combined with RAGE, the expression of RAGE was up-regulated and PKCβ1 was activated together with TLR4, phosphorylated PKCβ1 was transferred from the cytoplasm to the membrane, and formed RAGE-TLR4-pPKCβ1 complex, then activated the TLR4 signaling pathway through the phosphorylation of IRAK4, which promoted the phosphorylation of NF-κB, and further promoted the immune maturation of dendritic cells and the expression of inflammatory factors

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Molecular Medicine

ISSN: 1528-3658