Fig. 2
From: Immunometabolism in biofilm infection: lessons from cancer
The immune polarization during cancer. The tumor milieu can participate in the immunosuppression and diminished anti-tumoral functions of different immune cells and cause the immunoinhibitory phenotype of immune cells. For example, Th cell lineages, including Th1, Th2, and Th17, during cancer have been polarized to Th2 and regulatory T cells (Tregs); consequently, CTL-mediated cancer cell cytotoxicity can be hampered via recruitment and/or conversion of Tregs and myeloid-derived suppressor cells (MDSCs) (Hu et al. 2020)