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Fig. 9 | Molecular Medicine

Fig. 9

From: Eriodictyol ameliorates cognitive dysfunction in APP/PS1 mice by inhibiting ferroptosis via vitamin D receptor-mediated Nrf2 activation

Fig. 9

The mechanism by which eriodictyol inhibits AD. Eriodictyol alleviated cognitive injury by preventing neuronal ferroptosis, and its mechanism may be associated with VDR-mediated activation of Nrf2/HO-1 signaling. Eriodictyol up-regulated VDR expression and then activated the Nrf2/HO-1 signaling pathway by promoting the phosphorylation and nuclear translocation of Nrf2, thus regulating the expression of proteins related to ferroptosis

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Molecular Medicine

ISSN: 1528-3658