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Table 1 Baseline characteristics of participants included in the study

From: NK cell frequencies, function and correlates to vaccine outcome in BNT162b2 mRNA anti-SARS-CoV-2 vaccinated healthy and immunocompromised individuals

 

Healthy Individudals (n = 41)

Primary Immuno-deficiencies (n = 16)

People Living With HIV (n = 48)

Solid Organ Transplantation (n = 34*)

Sex, n (%)

 Men

19 (46%)

8 (50%)

26 (54%)

18 (53%)

 Women

22 (54%)

8 (50%)

22 46%)

16 (47%)

Age < 65 years, n (%)

28 (68%)

13 (81%)

37 (77%)

24 (71%)

Ongoing immune-suppression, n (%)

 Corticosteroids

0

0

0

32 (94%)

 Other immune-suppressive agents

0

1 (6%)

0

34 (100%)

Subgroups (n)

1. 18–39 years (n = 16)

2. 40–59 years (n = 12)

3. > 60 years (n = 13)

1. CVID (n = 3)

2. Low number or defect

T-cell function (n = 8)

3. Monogenic diseases (n = 2)

4. Other with expected

normal response (n = 3)

1. Latest CD4 T cell count ≤ 300 cells/μl (n = 16)

2. Latest CD4 T cell count > 300 cells/μl (n = 32)

Time after transplantation:

1. ≤ 6 mo (n = 19)

with/without MMF

2. > 6 mo with MMF

(n = 6)

3. > 6 mo without

MMF (n = 9)

  1. n number, HIV human immunodeficiency virus, CVID common variable immunodeficiency, IgA immunoglobulin A, CD cluster of differentiation, MMF mycophenolate mofetil.
  2. *The different transplants in the SOT group (n = 34) were liver (n = 19), kidney (n = 14) and kidney and pancreas (n = 1)