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Fig. 7 | Molecular Medicine

Fig. 7

From: Antibody-drug conjugates targeting CD248 inhibits liver fibrosis through specific killing on myofibroblasts

Fig. 7

Biosafety and reproductive safety analysis of IgG78-DM1 in C57BL/6 mice. A, B Food intake and body weight of different groups after IgG78-DM1 or hIgG-DM1 treatment. CE Kidney function, liver index (liver weight/body weight), and liver function showing the biosafety of IgG78-DM1 in CCl4-induced mice. F H&E staining of different organs in CCl4-induced mice after IgG78-DM1 or hIgG-DM1 treatment (n = 5 in AF). Scale bar, 50 μm. G H&E staining of embryos in early, middle, and late stages of pregnancy in normal C57BL/6 mice after IgG78-DM1 or hIgG-DM1 treatment. HK Duration of pregnancy, change in body weight during pregnancy, number of offspring, and weight of the pups in each group (n = 5 in GK). Representative images are shown. DM1 Mertansine, H&E hematoxylin and eosin

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