Fig. 7
Biosafety and reproductive safety analysis of IgG78-DM1 in C57BL/6 mice. A, B Food intake and body weight of different groups after IgG78-DM1 or hIgG-DM1 treatment. C–E Kidney function, liver index (liver weight/body weight), and liver function showing the biosafety of IgG78-DM1 in CCl4-induced mice. F H&E staining of different organs in CCl4-induced mice after IgG78-DM1 or hIgG-DM1 treatment (n = 5 in A–F). Scale bar, 50 μm. G H&E staining of embryos in early, middle, and late stages of pregnancy in normal C57BL/6 mice after IgG78-DM1 or hIgG-DM1 treatment. H–K Duration of pregnancy, change in body weight during pregnancy, number of offspring, and weight of the pups in each group (n = 5 in G–K). Representative images are shown. DM1 Mertansine, H&E hematoxylin and eosin