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Fig. 5 | Molecular Medicine

Fig. 5

From: Involvement of the TNF-α/SATB2 axis in the induced apoptosis and inhibited autophagy of osteoblasts by the antipsychotic Risperidone

Fig. 5

Risperidone inhibits osteoblast differentiation through the TNF-α/SATB2 axis. A the mRNA expression of OPG, collagen I and RANKL in MC3T3-E1 cells determined by RT-qPCR. B Western blot analysis of OPG, collagen I and RANKL expression in MC3T3-E1 cells. The protein band was assessed. C repesentative images and statistical analysis of positive Alizarin red S staining in MC3T3-E1 cells. D repesentative images and statistical analysis of positive ALP staining in MC3T3-E1 cells. *p < 0.05, compared with MC3T3-E1 cells treated with si-NC. #p < 0.05, compared with MC3T3-E1 cells treated with Risperidone + si-NC. &p < 0.05, compared with MC3T3-E1 cells treated with Risperidone + si-TNF-α. The cell experiments are repeated 3 times

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Molecular Medicine

ISSN: 1528-3658