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Table 3 Cox proportional hazard model of clinical parameters and TMEM240 DNA methylation level associated with breast cancer

From: Hypermethylation of TMEM240 predicts poor hormone therapy response and disease progression in breast cancer

Breast cancer

10-year overall survivala

Univariate analysis

Multivariate analysis

Variable

HR

95% CI

P-value

HR

95% CI

P-value

Race

0.902

0.568–1.433

0.662

1.389

0.553–3.489

0.484

Age

2.055

1.366–3.091

0.001***

1.516

0.508–4.529

0.456

Tumor type

1.391

1.028–1.882

0.033*

1.241

0.567–2.716

0.588

Stage

2.052

1.311–3.213

0.002**

4.098

1.551–10.827

0.004***

Menopause

1.256

0.904–1.746

0.174

1.498

0.787–2.815

0.221

TMEM240

2.747

1.364–5.531

0.005**

6.172

1.984–19.197

0.002**

  1. aThese results were analyzed by the Cox regression model
  2. bThe TMEM240 DNA methylation levels were derived from 640 breast cancer patients in TCGA data set
  3. c*P < 0.05; **P < 0.01; ***P < 0.001
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Molecular Medicine

ISSN: 1528-3658