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Fig. 5 | Molecular Medicine

Fig. 5

From: Protective role of trametenolic acid B against sevoflurane-induced cognitive impairments by its different regulatory modalities of mir-329-3p in neurons and microglia

Fig. 5

miR-329-3p mediated the effects of TAB on PC12 cell viability and HAPI inflammation. A, B miR-329-3p was significantly upregulated by the miR-329-3p mimic, but was downregulated by the miR-329-3p inhibitor. C, D The effects of TAB on PC12 cell viability and apoptosis were reversed by miR-329-3p overexpression, but were enhanced by miR-329-3p inhibition. E–G The reduced IL-1β (E), IL-6 (F) and TNF-α G induced by TAB were further inhibited by miR-329-3p overexpression, but was elevated by the knockdown of miR-329-3p. **P < 0.01, ***P < 0.001 compared to SEV; #P <0.05, ##P <0.01, ###P < 0.001 compared to SEV+TAB.

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Molecular Medicine

ISSN: 1528-3658