Fig. 6From: EGF signaling promotes the lineage conversion of astrocytes into oligodendrocytesProposed model of synergistic induction of transdifferentiation from astrocytes to oligodendrocytes by EGF and Sox10. EGF binds to EGFR to activate the downstream Erk pathway, thereby up-regulating the expression of oligodendrogenic genes, meanwhile, forced expression of Sox10 in astrocytes also promotes Olig2 expression and facilitates astrocyte reprogramming to iOPCs via APCsBack to article page