Fig. 4

The effect of Glab on renal function. A H&E, B PAS, and C Sirius red staining of renal tissues (magnification 200 × ; bar = 100 μm). D Alloknesis score was recorded to evaluate mechanical itch behavior. E Kidney weight and (F) index. The renal function was assessed by detecting (G) serum creatinine (Scr), (H) blood urea nitrogen (BUN), and (I) urinary albumin excretion rate (UAER). J Kidney damage biomarkers (KIM-1, NGAL, and TIMP-1) in urinary excretion were detected by western blot (^***P < 0.005, vs. the control group; ^##P < 0.01 and ^###P < 0.005, vs. the DM group)