Fig. 2
From: Famotidine activates the vagus nerve inflammatory reflex to attenuate cytokine storm
Famotidine is more potent when administered into the central nervous system. A–D Famotidine (intracerebroventrical, ICV) injection attenuated LPS-induced systemic TNF and IL-6 release in mice. Male C57BL/6 mice had ICV injection of PBS or famotidine (0.04 or 0.4 mg/kg in 5 µl volume) 30 min before LPS. LPS was administered IP at 7 mg/kg. Mice were euthanized 2.5 h post-LPS injection and serum and spleen were harvested for analyses. N = 5 for normal group. N = 10 for FM alone. N = 13 or 14 for other groups. *P < 0.05,. **P < 0.01.***P < 0.001, ****P < 0.0001