Fig. 5
From: ISM1 suppresses LPS-induced acute lung injury and post-injury lung fibrosis in mice
ISM1 deficiency enhances lung fibrosis post LPS-triggered ALI. a Representative images of H & E stained lung tissue sections showing the extent of fibrosis in wild-type (WT) and Ism1−/− mice at day 9 post LPS challenge. b, c Collagen deposition, detected by Picro-sirius staining, was higher in the lungs of Ism1−/− mice as compared to those of WT mice. d, e Increased presence of contractile myofibroblasts within fibrotic foci (detected by α-SMA staining) in Ism1−/− lungs as compared with those of WT. ** represents p < 0.01. n = 3 mice per group, 2 sections per lung, 5 microscopic fields per section were analyzed