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Fig. 6 | Molecular Medicine

Fig. 6

From: Farnesyl diphosphate synthase regulated endothelial proliferation and autophagy during rat pulmonary arterial hypertension induced by monocrotaline

Fig. 6

Illustration of the role of FDPS on autophagy in PAECs upon PAH. FDPS expression is up-regulated in pulmonary artery after MCT treatment, which consequently leads to an increase of PAECs autophagy level through the PI3K/AKT/mTOR pathway. Additionally, FDPS may also increase activation of Rac1. Inhibition of FDPS or Rac1 reduces PAECs autophagy and proliferation

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Molecular Medicine

ISSN: 1528-3658