Table 13 Major genes targeted by miR-375-3p in various types of cancer

Cancers with down-regulation of miR-375-3p

Acting as oncogenes or tumor promoters

CRC

TYMS, CBX3, FOXM1,

Xu et al. (2020b); Liu et al. (2020a); Chen et al. (2020b);

FZD8, PIK3CA, YAP1

Xu et al. (2016a); Wang et al. (2014b Xu et al. (2019a

ESCC

MTDH

Hu et al. (2017b)

GC

PDPK1, TEAD4, YAP1,

Chen et al. (2017d); Kang et al. (2018)

YBX1, YWHAZ

Huang et al. (2019b); Liu et al. (2019b)

OSCC

SLC7A11

Wu et al. (2017)

NSCLC

SPIN1

Jin et al. (2021)

HCC

ERBB2, HMGA2, JAK2

Li et al. (2018b); Xu et al. (2021); Li et al. (2021b)

HCC

MTDH, PDGFC, YAP1

He et al. (2012); Li et al. (2021c); Liu et al. (2010)

HCC CSCs

YAP1

Zhao et al. (2020a)

PDAC

PDPK1, ZFP36L2

Zhou et al. (2014b); Song et al. (2013a); Yonemori et al. (2017)

OVCA

YAP1

Shu et al. (2021)

Acting both as oncogenes and tumor suppressors, or unclassified

CRC

KLF4, SP1

Mao et al. (2016); Xu et al. (2019a)

GC

CCN2

Kang et al. (2018)

ESCC

HMGB1, IGF1R, SESN3,

Cheng et al. (2020b); Kong et al. (2012); Li et al. (2021a)

SP1

Xu et al. (2019b)

LSCC

HNF1B, IGF1R

Chang et al. (2020); Luo et al. (2014)

OSCC

KLF5, IGF1R, PAX6

Shi et al. (2015); Zhang et al. (2017); Tong et al. (2021)

CeCa

SP1

Wang et al. (2011)

Cancers with up-regulation of miR-375-3p

Acting as tumor suppressors

BRCA

FOXO1

Guan et al. (2021)

CeCa

CDH1

Shen et al. (2014)

Acting both as oncogenes and tumor suppressors, or unclassified

PDAC

HOXB3

Yang et al. (2016)