MALAT1-miRNAs network regulate thymidylate synthase and affect 5FU-based chemotherapy

Table 17 Major genes targeted by miR-1307-3p in various types of cancer

Cancers	Targeted gene products†	References
Cancers with down-regulation of miR-1307-3p
	Acting as oncogenes or tumor promoters
CRC	TYMS	Chen et al. (2017a)
	Acting as tumor suppressors
CRC	ISM1	Zheng et al. (2019a); Yue et al. (2020)
Cancers with up-regulation of miR-1307-3p
	Acting as tumor suppressors
CRC	TRARG1	Zheng et al. (2019a)
GC	DAB2IP	Ma et al. (2021b)
BLCA	SMG1	Wang et al. (2021b)
BRCA	SMYD4	Han et al. (2019)
HCC	DAB2IP, ISM1	Chen et al. (2019a); Wang et al. (2019b)
OVCA	DAPK3	Zhou et al. (2015)
PCa	FOXO3	Qiu and Dou (2017)

^†mRNAs encoding the following proteins: DAB2IP is a tumor suppressor gene encoding DAB2 Interacting Protein, a Ras GTPase-activating protein; DAPK3 is a tumor suppressor gene that codes for serine/threonine Death Associated Protein Kinase 3; FOXO3 is a tumor suppressor gene encoding a transcription factor that activates genes encoding i.a. pro-apoptotic BIM and PUMA; ISM1 codes for Isthmin 1 that acts as an angiogenesis inhibitor; SMG1 is a tumor suppressor gene encoding a protein that can enhance p53 activity (Gewandter et al. 2011); SMYD4 is a tumor suppressor gene involved in the development of breast cancer; TRARG1 codes for Trafficking Regulator of GLUT4

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