MALAT1-miRNAs network regulate thymidylate synthase and affect 5FU-based chemotherapy

Table 3 Major genes targeted by miR-192-5p and miR-215-5p in various types of cancer

Cancers	Targeted gene products^†	References
Cancers with down-regulation of miR-192/215-5p
	Acting as oncogenes or tumor promoters
CRC	TYMS, EIF5A2, EREG, HOXB9	Boni et al. (2010); Song et al. (2010); Zhao et al. (2020b); Chen et al. (2016)
	RAB2A, YY1, ZEB2	Vychytilova et al. (2017); Zheng et al. (2019b); Chen et al. (2017c)
BRCA	AKT1, RAD54B, SOX9	Yao et al. (2017); Wang et al. (2021i); Gao et al. (2019)
NSCLC	TRIM44	Zou et al. (2019)
BLCA	YY1	Ji et al. (2018)
HCC	CDC6, SLC39A6, TRIM25	Xu et al. (2020a); Lian et al. (2016); Wang et al. (2021h)
PCa	NOB1	Sun et al. (2016)
Cancers with up-regulation of miR-192/215-5p
	Acting as tumor suppressors
GC	RB1, RUNX1	Chen et al. (2017e); Deng et al. (2014b); Li et al. (2016
ESCC	BCL2L11	Li et al. (2015c)

^†mRNAs encoding the following proteins: AKT1 encodes AKT Serine/Threonine Kinase 1; BCL2L11 codes for pro-apoptotic BH3-only protein BIM; CDC6 is an oncogene encoding Cell Division Cycle 6 Homolog; EIF5A2 is an oncogene encoding Eukaryotic Translation Initiation Factor 5A2; EREG codes for Epiregulin, ligand of epidermal growth factor receptor (Cheng et al. (2021); HOXB9 encodes transcription factor Homeobox B9 (Contarelli et al. 2020); NOB1 is an oncogene encoding Nin One Binding Protein; RAB2A is an oncogene encoding a member of the RAS family; RAD54B is an oncogene encoding helicase RAD54 Homolog B involved in homologous recombination and DNA repair (Zhang et al. 2019c); RB1 is a tumor suppressor gene encoding RB Transcriptional Corepressor 1, a key regulator of the G1/S transition in the cell cycle; RUNX1 is tumor suppressor gene coding for RUNX Family Transcription Factor 1; SLC39A6 is an oncogene that encodes a zinc-influx transporter; SOX9 is an oncogene encoding SRY-Box Transcription Factor 9; TRIM25 encodes E3 ubiquitin ligase involved in p53 inactivation (Zhang et al. 2015); TRIM44 is an oncogene encoding a protein involved in the ubiquitination and degradation of target proteins; YY1 is an oncogene encoding Yin Yang 1 transcriptional factor; ZEB2 encodes Zinc Finger E-Box Binding Homeobox 2, a transcriptional corepressor promoting the EMT process in cancer cells

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