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Fig. 4 | Molecular Medicine

Fig. 4

From: Activation of the sigma-1 receptor exerts cardioprotection in a rodent model of chronic heart failure by stimulation of angiogenesis

Fig. 4

Stimulation of the sigma-1 receptor moderated the proangiogenic switch via JAK2/STAT3 signaling pathway in PIHF rats. A Immunofluorescence staining showing intracellular localization of S1R (red); B S1R stimulation ameliorated angiogenesis, evidenced by the CD31 and PCNA double immunohistochemical staining; C S1R stimulation promote mature vascular lumen generation by the α-sma immunohistochemical staining; D Quantitative analysis results of CD31 + and SMA + vessels; E Western blot results showed that stimulation of S1R upregulated the JAK2/STAT3 signaling pathway to pro-angiogenesis. N = 3 for quantified analysis. *P < 0.05; **P < 0.01; ***P < 0.005; ****P < 0.001

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Molecular Medicine

ISSN: 1528-3658