Fig. 4

SHP-1 agonist inactivates Lyn signaling and elicits PAPR cleavage. A Whole-cell extracts of U2932 and OCI-Ly7 cells treated with SC-43 or ibrutinib at indicated doses for 24 h were analyzed by Western blot analysis (left). The quantitative results of blotting were shown (right). B Whole-cell extracts of U2932 and OCI-Ly7 cells treated with SC-43 or ibrutinib at 5 μM for indicated times were examined by Western blot analysis (left). The quantitative results of blotting were shown (right). Data are representative of three independent experiments. Student’s t-test, *P < 0.05; **P < 0.01; ***P < 0.001