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Fig. 1 | Molecular Medicine

Fig. 1

From: Temporal changes in cyclinD-CDK4/CDK6 and cyclinE-CDK2 pathways: implications for the mechanism of deficient decidualization in an immune-based mouse model of unexplained recurrent spontaneous abortion

Fig. 1

The histomorphology and abortion rate in NP and URSA groups (mean ± SD). A On GD8, the uterus of the NP group exhibited normal shape with clearly visible implanted embryos. Immature, absorbed, or dead implanted embryos were often found in the URSA group. Arrowheads point to absorbed and necrotic sites. B The abortion rate (mean ± SEM, %) on GD8 was significantly higher in the URSA group compared to that in the NP group. Abortion rate = ratio of absorbed and necrotic embryos to the total number of implanted embryos. *Significantly different (p < 0.005) between null vs. NP. (n = 5 in A–B); C. 50 × , 200 × , and 400 × magnification images of enucleated decidual tissue stained for hematoxylin and eosin taken after whole tissue scanning. Arrowheads point to pathological form sites. Scale bar, 100 μm. GD8, gestation day 8; NP, normal pregnancy; URSA, unexplained recurrent spontaneous abortion

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Molecular Medicine

ISSN: 1528-3658