Fig. 5
From: Genetic control of neuronal activity enhances axonal growth only on permissive substrates
Increasing neuronal activity does not induce recovery after CNS injury. A Timeline of the CST injury and stimulation experiments. B, C % of missteps in the gridwalk test (B) (n = 8–9 mice per group for each timepoint) and BMS score (C) (n = 10 mice per group for each timepoint) show no differences in sensorimotor recovery in stimulated Thy1-ChR2 (ChR2 Light) mice when compared to non-stimulated (ChR2 No light) after CST injury. D Timeline of the DCA and stimulation experiments. E, F Chemogenetically stimulated animals (hM3Dq-CNO) show similar sensorimotor function recovery to non-stimulated ones (mCherry-CNO, mCherry-veh, hM3Dq-veh) after DCA as seen by the gridwalk (E) (n = 3–5 mice per group for each timepoint) and BMS (F) (n = 5–6 mice per group for each timepoint) tests. Represented data correspond to the BMS score and % of missteps in the gridwalk. Data are expressed as mean ± s.e.m. ANOVA followed by Bonferroni post-hoctest