Fig. 2
hUCMSCs@Ex-4 reduces blood glucose levels and promotes the repair of islet tissue damage in T1DM mice. A Curve showing body weight changes of T1MD mice with different treatments. B Curve for blood glucose changes of T1MD mice with different treatment. C Blood glucose level in T1MD mice with different treatments, determined by OGTT. D, Fasting serum C peptide levels in T1MD mice with different treatments, analyzed by ELISA. E HE staining of islet morphology in T1MD mice with different treatments (400 ×). F Immunohistochemical staining analysis of the infiltration of immune cells in the pancreatic tissues of T1MD mice with different treatments. G Proportion of β-cells in the pancreatic tissues of T1MD mice with different treatments, analyzed by immunohistochemical staining for insulin. H Proportion of α-cells in the pancreatic tissues of T1MD mice with different treatments, analyzed by immunohistochemical staining for glucagon. I TUNEL-positive islet cells in the pancreatic tissues of T1MD mice with different treatments. J Ki67 immunohistochemical staining of islet cells in the pancreatic tissues of T1MD mice with different treatments. In panels, *p < 0.05 vs. T1DM mice. #p < 0.05 vs. T1DM mice treated with hUCMSCs@Ex-4 vs. T1DM mice treated with hUCMSCs. In F–J, *p < 0.05 vs. PBS-treated mice. #p < 0.05 vs. T1DM mice. &p < 0.05 vs. T1DM mice treated with hUCMSCs