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Fig. 7 | Molecular Medicine

Fig. 7

From: LINC00240/miR-155 axis regulates function of trophoblasts and M2 macrophage polarization via modulating oxidative stress-induced pyroptosis in preeclampsia

Fig. 7

LINC00240 overexpression ameliorates symptoms of preeclampsia in vivo. A Blood pressure of rats was monitored on embryonic day 0, 3, 6 and every 3 days thereafter. B Urine protein levels were monitored on embryonic day 0, 3, 6 and every 3 days thereafter. C Fetal lengths of rats were measured on embryonic day 20. D Fetal weights of rats were measured on embryonic day 20. E Kidney and liver injuries were measured using H&E staining. Scale bar: 100 μm. F CK7 expression was examined using immunohistochemistry in placenta tissues of rats. Scale bar: 100 μm. G Arg-1 and iNOS mRNA levels in placenta tissues were measured using qPCR. H HO-1 and eNOS mRNA levels in placenta tissues were measured using qPCR. I NLRP3 and HMGB1 mRNA levels in placenta tissues were measured using qPCR. J LINC00240, miR-155 and Nrf2 levels in placenta tissues were measured using qPCR. K Nrf2 protein levels in placenta tissues were measured using western blotting. All the experiments were repeated at least three times. *P < 0.05, **P < 0.01 and ***P < 0.001

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Molecular Medicine

ISSN: 1528-3658