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Fig. 7 | Molecular Medicine

Fig. 7

From: Spermidine protects against acute kidney injury by modulating macrophage NLRP3 inflammasome activation and mitochondrial respiration in an eIF5A hypusination-related pathway

Fig. 7

Schematic overview of the protection of spermidine against sepsis-induced AKI. Spermidine protects against AKI by inhibiting macrophage inflammatory responses. LPS activated NLRP3 inflammasome and thereby promoted IL-1β production and secretion in macrophages. In contrast, spermidine downregulates NLRP3 inflammasome activation and IL-1β production in macrophages. Mechanically, spermidine enhances oxidative phosphorylation (OXPHOS) and reduces mitochondrial ROS (mtROS) overload, which contribute to the NLRP3 inhibition. Importantly, eIF5A hypusination can mediate the effects of spermidine on macrophages

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Molecular Medicine

ISSN: 1528-3658