Fig. 3
From: Stem cell therapy as a promising strategy in necrotizing enterocolitis
Stem cells from various sources are transplanted into NEC models. First, stem cells are isolated and extracted from various tissues including the intestine, bone marrow, amniotic fluid, umbilical cord, and placenta. Among, ISC and E-NSC are autologous, BM-MSC, AF-MSC, UC-MSC, P-MSC, and AF-NSC can be administered into NEC animal models by the donor or autologous transplantation. Then, extracted stem cells are propagated in an incubator. Finally, these cultured stem cells will be transported into NEC animal models via IP or IV injection. BM-MSC bone marrow-derived mesenchymal stem cell; UC-MSC umbilical cord-derived stem cell; AF-MSC amniotic fluid-derived mesenchymal stem cell; AF-NSC neural stem cell isolated from the amniotic fluid; E-NSC enteric neural stem cell; ISC Intestinal stem cell; P-MSC placental-derived mesenchymal stem cell; IP intraperitoneal; IV intravenous