Skip to main content
Fig. 1 | Molecular Medicine

Fig. 1

From: The interaction between autophagy and the epithelial-mesenchymal transition mediated by NICD/ULK1 is involved in the formation of diabetic cataracts

Fig. 1

Rapamycin prevented the formation of cataracts in diabetic rats. Diabetic rats (DC) were induced by STZ. Rats in the normal control group (NC) were injected with the corresponding volume of citric acid-sodium citrate buffer. Diabetic rats were treated with DMSO solvent (DMSO) and rapamycin (RAPA) respectively. Body weight (A, n = 10) and random blood glucose levels (B, n = 10) of rats were examined after treatment with rapamycin for 0 (before treatment), 4 and 8 w. (C, D) Lenses of rats in each group (n = 20) were observed and photographed under a slit lamp microscope at 0 w, 4 w and 8 w after treatment with rapamycin. E, F H&E staining showed histological changes in the lens (n = 4). ns indicates P > 0.05; **P < 0.01 and ****P < 0.0001 vs. NC group; #P < 0.05 and ###P < 0.001 vs. DC group; ★P < 0.05 and ★★P < 0.01 vs. DMSO group

Back to article page

Molecular Medicine

ISSN: 1528-3658