Table 1 843 HNF1A variant carriers characteristics in the discovery cohort
Country | N | Males, % | Mean age (SD), years | Mean age at onset (SD), years | No. of causative variants per HNF1A domain | ||
|---|---|---|---|---|---|---|---|
DNA-binding | Dimeri-zation | Trans-activation | |||||
Czech Republic | 89 | 34 | 43.63 (15.53) | 20.04 (9.28) | 50 | 2 | 37 |
France | 277 | 32 | 44.34 (15.81) | 21.79 (10.32) | 124 | 20 | 133 |
Poland | 85 | 25 | 47.09 (15.29) | 24.30 (10.54) | 51 | 6 | 28 |
Slovakia | 59 | 49 | 42.95 (15.06) | 19.96 (9.39) | 41 | 2 | 16 |
UK | 242 | 30 | 56.14 (18.24) | 22.00 (11.55) | 90 | 6 | 146 |
USA | 91 | 50 | 64.89 (18.13) | 25.11 (15.36) | 51 | 6 | 34 |
p-value | – | 7.12E−04 | < 2E−16 | 0.0127 | 1.80E−06 | ||