Variants influencing age at diagnosis of HNF1A-MODY

Table 5 Influence of common variants in HNF1A target genes on age at diagnosis

Gene	SNP ID	Effective allele	Est. G	Est. G:D domain	Est. G:T domain	GxE p-value
AFP/AFM	rs12510870	C	− 0.0658	0.0782	0.1418	0.0096
	rs16849364	G	− 0.0472	0.0322	0.1290	0.0218
	rs4640638	G	− 0.0437	0.0449	0.1211	0.0355
CYP1A2	rs12441817	C	0.0228	− 0.4899	− 0.0044	0.0109
SLCO1B3	rs10841644	C	− 0.0049	0.2745	0.0089	0.0089
	rs7965380	C	− 0.0019	0.2716	0.0073	0.0097
	rs957164	G	0.0031	0.2797	− 0.0138	0.0103
	rs2033515	G	− 0.0406	0.3366	0.0458	0.0193
MTTP	rs12647527	G	− 0.0063	− 0.1420	0.0376	0.0050
MTTP	rs881980	G	− 0.0025	− 0.4047	0.0365	0.0094
CRP	rs12094103	G	0.01945	− 0.2369	− 0.0718	0.0115
CRP	rs3122012	C	0.0116	− 0.2509	− 0.0597	0.0123
CSRP1	rs7525711	G	− 0.0186	− 0.2557	0.0517	0.0063
	rs11577209	G	− 0.0115	− 0.1766	0.0833	0.0111
	rs10920205	G	− 0.0061	− 0.2557	0.0100	0.0139
	rs2038972	C	− 0.0466	0.0086	0.1344	0.0286

D dimerization domain, HNF1A hepatocyte nuclear factor-1-alpha, ID identifier, SNP single-nucleotide polymorphism, T transactivation domain, Est G. main effect of the risk allele estimated in the Linear Mixed Model; Est G:D the estimated interaction effect of the risk allele and the indicator variable of the dimerization domain; Est G:T the estimated interaction effect of the risk allele and the indicator variable of the transactivation domain; GxE p-value: the p-value for the null hypothesis that the Est G:T and Est G:D equal zero; Joint p-value the p-value for the null hypothesis that Est G, Est G:T and Est G:D equal zero

ISSN: 1528-3658