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Table 3 MR estimates of IgG glycans with T2D in the European population

From: Immunoglobulin G N-glycan, inflammation and type 2 diabetes in East Asian and European populations: a Mendelian randomization study

Exposure

SNPs

IVW

WM

PWM

MR-Egger

Ppleiotropy

Pheterogeneity

  

OR (95%CI)

P

OR (95%CI)

P

OR (95%CI)

P

OR (95%CI)

P

  

GP2

7

0.999(0.965–1.034)

0.9497

1.009(0.971–1.048)

0.6515

1.010(0.969–1.052)

0.6251

1.042(0.947–1.146)

0.4365

0.3931

0.2717

GP4

2

0.985(0.846–1.148)

0.8530

–

0.0881

GP6

4

0.999(0.910–1.099)

0.9992

0.966(0.896–1.042)

0.3766

0.956(0.884–1.034)

0.2642

1.049(0.459–2.856)

0.8005

0.7990

0.0361

GP7

5

0.979(0.933–1.028)

0.4033

0.993(0.941–1.049)

0.8131

0.994(0.941–1.049)

0.8215

1.055(0.953–1.168)

0.2080

0.2080

0.3010

GP8

2

1.041(0.923–1.174)

0.5147

–

0.1993

GP9

4

0.899(0.845–0.957)

0.0008

0.924(0.866–0.985)

0.0198

0.924(0.868–0.984)

0.0198

1.046(0.853–1.284)

0.7046

0.2723

0.2293

GP10

5

0.997(0.929–1.068)

0.9256

0.963(0.910–1.018)

0.1831

0.951(0.902–1.002)

0.0617

1.033(0.820–1.301)

0.8003

0.7669

0.0137

GP11

3

1.003(0.869–1.156)

0.9708

0.938(0.867–1.014)

0.1077

0.937(0.869–1.012)

0.0957

0.925(0.476–1.799)

0.8455

0.8455

0.0035

GP12

3

1.008(0.958–1.060)

0.7625

1.009(0.955–1.067)

0.7363

1.009(0.955–1.067)

0.7361

1.046(0.903–1.213)

0.6546

0.6890

0.8679

GP13

3

1.008(0.958–1.060)

0.7625

1.009(0.956–1.066)

0.7324

1.009(0.954–1.067)

0.7405

1.046(0.903–1.212)

0.6546

0.6890

0.8679

GP14

4

0.992(0.887–1.108)

0.8824

0.928(0.905–1.043)

0.4290

0.928(0.853–1.009)

0.0838

0.936(0.538–1.627)

0.8365

0.8524

0.0034

GP15

7

0.981(0.907–1.061)

0.6331

0.966(0.900–1.035)

0.3258

0.951(0.889–1.016)

0.1361

0.939(0.551–1.603)

0.8283

0.8791

0.0053

GP16

5

1.017(0.981–1.054)

0.3652

1.032(1.003–1.062)

0.0304

1.033(1.004–1.063)

0.0248

1.099(1.028–1.175)

0.0691

0.0910

0.0655

GP18

3

1.057(0.984–1.136)

0.1281

1.064(1.000–1.132)

0.0499

1.064(1.000–1.132)

0.0490

1.216(0.684–2.162)

0.6246

0.7125

0.1389

GP20

2

0.925(0.561–1.524)

0.7289

–

 < 0.0001

GP22

2

1.014(0.931–1.104)

0.7502

–

0.4754

GP23

3

1.022(0.895–1.167)

0.7487

1.058(0.976–1.147)

0.1705

1.093(1.018–1.173)

0.0135

0.026(0.003–2.425)

0.1793

0.1782

0.0016

  1. MR Mendelian randomization, IVW inverse variance weighting, WM weighted median, PWM penalized weighted median, OR odds ratio, CI confidence interval, SNP single-nucleotide polymorphism, GP glycan peak, Pheterogeneity is the P-value of Cochrane’s Q value in heterogeneity test by performing Inverse variance weighted method; Ppleiotropy is the P-value of MR-Egger intercept
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Molecular Medicine

ISSN: 1528-3658