Skip to main content
Fig. 1 | Molecular Medicine

Fig. 1

From: O-GlcNAcylation: an important post-translational modification and a potential therapeutic target for cancer therapy

Fig. 1

The process of hexosamine biosynthetic pathway (HBP) and O-GlcNAcylation. HBP integrates multiple metabolic pathways and the end product UDP-GlcNAc acts as a sugar donor for protein O-GlcNAcylation. HK hexokinase, GPI glucose-6-phosphate isomerase, GFAT glutamine:fructose-6-phosphate amidotransferase, GNAT glucosamine 6-phosphate N-acetyltransferase, PGM phosphoglucomutase, UAP UDP-N-acetylglucosamine pyrophosphorylase, TCA tricarboxylic acid cycle, OXPHOS oxidative phosphorylation

Back to article page

Molecular Medicine

ISSN: 1528-3658