O-GlcNAcylation: an important post-translational modification and a potential therapeutic target for cancer therapy

Table 1 The overlapping sites of O-GlcANc and cancer mutation

Gene	Mutation proportion (%)	Protein	Uniprot ID	O-GlcNAc site	Cancer Type	Overlapping site	Protein Change	Annotation
TP53	37	P53	P04637	S149	Serous Ovarian Cancer	S149	S149Ffs32*	The TP53 S149Ffs*32 mutation is likely oncogenic
					Prostate Adenocarcinoma	S149	S149Pfs21*	The TP53 S149Pfs*21 mutation is likely oncogenic
					Pancreatic Adenocarcinoma	S149	S149Ffs32*	The TP53 S149Ffs*32 mutation is likely oncogenic
TTN	30	TITIN	Q8WZ42	T671, T826, S1571, T3501, S4651, T4659, S7613, S10385, S10781, T12007, T14674, S28157, S28450, S33976	Uterine Endometrioid Carcinoma	T671	T671S	Unknown
					Uterine Endometrioid Carcinoma	S1571	S1571T	Unknown
					Cutaneous Melanoma	S1571	S1571F	Unknown
MUC16	19.3	MUC16	Q8WXI7	S12117, S13054, T13833	Uterine Endometrioid Carcinoma	S12117	S12117N	Unknown
					Renal Clear Cell Carcinoma	S13054	S13054T	Unknown
					Renal Clear Cell Carcinoma	S13054	S13054F	Unknown
PIK3CA	14.1	PK3CA	P42336	no data
CSMD3	13.3	CSMD3	Q7Z407	no data
RYR2	13.2	RYR2	Q92736	T1468		No overlapping sites
LRP1B	12.7	LRP1B	Q9NZR2	no data
SYNE1	12.2	SYNE1	Q8NF91	S1286, T1951, S3382, T4836, T7270	Serous Ovarian Cancer	T1951	T1951A	Unknown
SYNE1	12.2	SYNE1	Q8NF91	S1286, T1951, S3382, T4836, T7270	Cutaneous Melanoma	S3382	S3382N	Unknown
FLG	11.4	FILA	P20930	na
USH2A	11.2	USH2A	O75445	na

no data: could not find human protein in O-GlcNAc database, na: no O-GlcNAc site reported

ISSN: 1528-3658