Skip to main content
Fig. 11 | Molecular Medicine

Fig. 11

From: miR-351 promotes atherosclerosis in diabetes by inhibiting the ITGB3/PIK3R1/Akt pathway and induces endothelial cell injury and lipid accumulation

Fig. 11

miR-351 abolished ITGB3 expression and the PI3K/Akt pathway in high-fat diet-induced atherosclerosis in T2DM mice. In the high-fat diet-induced atherosclerotic T2DM mouse model, miR-351 was upregulated due to the influence of diabetes combined with a high-fat diet, while atherosclerosis was alleviated in the miR-351 KO mouse model. The reason is related to the inhibition of ITGB3 expression by miR-351. Downregulated ITGB3 cannot stimulate the activation of the PI3K/Akt pathway, resulting in decreased cell resistance to oxidative stress and survival. After miR-351 is eliminated, ITGB3's ability to stimulate the PI3K/Akt signaling pathway is restored, and endothelial cells can resist antioxidative stress and apoptosis and enhance cell survival

Back to article page

Molecular Medicine

ISSN: 1528-3658