Fig. 6
From: AAV-ie-mediated UCP2 overexpression accelerates inner hair cell loss during aging in vivo
UCP2 overexpression promotes IHC apoptosis in ARHL. A Representative IF images of TUNEL+ DAPI+ cells in the different groups. AAV-ie vector and IHCs were labeled with anti-GFP (green) and anti-Myosin VII (grey), respectively. Scale bar, 20 μm. B The ratio of IHC apoptosis in different groups (n = 4 ears/group). C Schematic model explaining the role of UCP2 based on our results in ARHL. UCP2 uncoupling protein 2, IHC inner hair cell, ARHL age-related hearing loss, ATP adenosine triphosphate, MMP mitochondrial membrane potential, pAMPK phosphorylated AMP-activated protein kinase, n.s. no significance, *p < 0.05, **p < 0.01