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Fig. 5 | Molecular Medicine

Fig. 5

From: SHP-1 knockdown suppresses mitochondrial biogenesis and aggravates mitochondria-dependent apoptosis induced by all trans retinal through the STING/AMPK pathways

Fig. 5

Inhibition of STING reverses mitochondrial biogenesis suppressed by SHP-1 knockdown. Scramble-rLV- and shRNA-SHP-1-rLV- transfected ARPE-19 cells were incubated with atRAL (7.5 μM, 24 h), with or without H151 (1 μM). A The relative ATP levels in different groups were measured. mtDNA content, represented by mt -ND1 (B), and mt-CO3 (C) was assessed by qPCR. D–H Western blotting analysis of TOMM20 (D, E), PGC-1α (F, G), and nrf2 (F, H). *P < 0.05 and **P < 0.01

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Molecular Medicine

ISSN: 1528-3658