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Fig. 6 | Molecular Medicine

Fig. 6

From: SHP-1 knockdown suppresses mitochondrial biogenesis and aggravates mitochondria-dependent apoptosis induced by all trans retinal through the STING/AMPK pathways

Fig. 6

Inhibition of AMPK partially abrogates the effects of STING inhibition. A–C Western blotting of phosphorylated TBK1/TBK1 (B) and phosphorylated AMPKα/AMPKα (C) in ARPE-19 cells exposed to atRAL (7.5 μM, 24 h), with or without H151(1 μM). D Viability of scramble-rLV- and shRNA-SHP-1-rLV-transfected ARPE-19 cells exposed to atRAL (7.5 μM, 24 h), after pretreatment with Compound C (5 μM) and H151 (1 μM) as indicated. E-I Western blotting analysis of PGC-1α (F), nrf2 (G), Bcl-xL (H) and TOMM20 (I). *P < 0.05 and **P < 0.01

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Molecular Medicine

ISSN: 1528-3658