Fig. 1

Protein structure and PTM sites of human FADD. The structural domains are presented in the bar. The well-known PTM sites are indicated at the corresponding position. The proteins interacting with FADD are exhibited above the lines at the corresponding domains. PTM, post-translational modification; FADD, Fas-associated protein with death domain; DED, ; DD, death effector domain; NLS, nuclear localization signal; NES, nuclear export signal; cFLIP, cellular FLICE (caspase 8)-inhibitory protein; DR, death receptor; RIPK1, receptor-interacting serine/threonine protein kinase 1; ATG5, autophagy related-protein 5