Table 1 NcRNAs targeting FADD in disease
Disease types | ncRNAs | Key messages | References |
|---|---|---|---|
Cancer | miR-128a | MiR-128a overexpression enhanced Fas-resistance on Jurkat cells by directly targeting FADD. MiR-128a knockdown sensitized Jurkat/R cells to the Fas-induced apoptosis through releasing FADD expression. | Yamada et al. (Yamada et al. 2014) |
|  | miR-633 | MiR-633 inhibited FADD expression by directly targeting its 3’UTR, leading to the enhancement of DOX/CDDP resistance in GC. | Pang et al. (Pang et al. 2019) |
| Â | H19 miR-675 | Overexpression of miR-675 derived from lncRNA H19 promoted liver necroptosis and cell death in HCC cells by targeting FADD. | Harari-Steinfeld et al. (Harari-Steinfeld et al. 2021) |
| Â | Â | Overexpression of H19 and miR-675 facilitated proliferation and suppressed apoptosis in GC cells by inhibiting the caspase cleavage cascades (caspase 8 and caspase 3) via downregulating FADD. | Yan et al. (Yan et al. 2017) |
| Â | Â | Overexpression of H19 increased PTK2 levels by targeting miR-138 and decreased FADD levels by targeting miR-675, leading to the inhibition of cell apoptosis and promotion of hepatoblastoma carcinogenesis. | Ge et al. (Ge et al. 2019) |
| Â | circ 001418 miR-1297 | Overexpression of circ 001418 facilitated cell proliferation and transfer, and reduced apoptosis by upregulating EphA2 and cytochrome c protein expression, and downregulating FADD via sponging miR-1297. | Peng et al. (Peng et al. 2021) |
Myocardial infarction | miR-103 | Inhibition of miR-103 significantly improved the myocardial infarction of mice by releasing FADD. | Zaafan et al. (Zaafan and Abdelhamid 2021) |
| Â | H19 miR-103/107 | FADD was upregulated by H19 via sponging miR-103/107. FADD upregulation promoted necrosis and improved myocardial infarction by influencing the formation of RIPK1 and RIPK3 complexes. | Wang et al. (Wang et al. 2015) |
Atherosclerosis | miR-155 | MiR-155 reduced the macrophage apoptosis by downregulating FADD via directly binding to its 3’-UTR region. | Zhu et al. (Zhu et al. 2013) |
Intervertebral disc degeneration | miR-155 | MiR-155 facilitated Fas-mediated apoptosis of nucleus pulposus cells by targeting FADD and caspase-3 via directly binding to their 3’-UTRs. | Wang et al. (Wang et al. 2011a) |