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Fig. 1 | Molecular Medicine

Fig. 1

From: SIGIRR deficiency contributes to CD4 T cell abnormalities by facilitating the IL1/C/EBPβ/TNF-α signaling axis in rheumatoid arthritis

Fig. 1

SIGIRR expression in human PBMCs and its protein interaction. SIGIRR expression in healthy human PBMCs revealed by single-cell RNA-seq (A–C, GSE112845) and bulk RNA-seq (D). A 2D visualization of single-cell clusters in healthy human PBMCs by t-SNE. Each dot represents a single cell. B Heatmap of 19 cell clusters identified by well-known unique signature genes. The Ζ-score, calculated on the basis of the permutation P value, is listed on the right side to show the gene expression level. C Violin plots showing the expression profile of SIGIRR across 19 clusters in human PBMCs. D Normalized transcript expression values (pTPM, transcripts per kilobase million) of SIGIRR in 18 hematopoietic cell types and total PBMCs of healthy donors by bulk RNA sequencing (available from v21.0.proteinatlas.org.). E SIGIRR network interaction revealed by the STRING online database

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Molecular Medicine

ISSN: 1528-3658