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Fig. 10 | Molecular Medicine

Fig. 10

From: Chronotherapeutic neuroprotective effect of verapamil against lipopolysaccharide-induced neuroinflammation in mice through modulation of calcium-dependent genes

Fig. 10

Effect of VRP on PKA, CREB, and BDNF. a Expression level of PKA, b Expression level of CREB, c Expression level of BDNF, d Band intensity of P-CREB for one representative sample for each studied group normalized against total CREB, e Column chart for relative expression of P-CREB, and f Concentration of BDNF. Data are expressed as the mean ± SD and were analyzed using one-way ANOVA followed by Tukey post hoc test. Values were considered significantly different at P < 0.05. a: significant versus normal control, b: significant versus LPS only, and c: significant versus morning VRP. LPS: lipopolysaccharides, VRP: verapamil, PKA: protein kinase A, CREB: cAMP response element-binding protein, P-CREB: phosphorylated CREB, BDNF: brain-derived neurotrophic factor

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Molecular Medicine

ISSN: 1528-3658