Fig. 5
From: A novel Mcl-1 inhibitor synergizes with venetoclax to induce apoptosis in cancer cells
MI-238 synergizes with venetoclax to induce apoptosis in AML cells. A–E Molm13 cells were treated with indicated concentrations of MI-238, venetoclax, or their combination for 48 h, followed by apoptosis assay by annexin V staining. Data are represented as mean ± SD from three independent replicates, **P < 0.01, ***P < 0.001, and ****P < 0.0001 by two-tailed t-test. F The combination index (CI) was calculated by CompuSyn software. G Molm13 and MV-4-11 cells were treated as indicated, and the caspase 3 cleavage was analyzed by western blot