Fig. 1

HYPERLINK "sps:id::fig1||locator::gr1||MediaObject::0" HOXA11-OS, Cyr61, Beclin-1, and LC3B are highly expressed in kidney tissues, serum, and cell lines of LN. A Expression of HOXA11-OS, Cyr61, Beclin-1, and LC3B in the kidney tissue of lupus mice and serum of lupus patients as detected by qRT-PCR and western blotting. ^*P < 0.05 vs. control group. Data are presented as means ± standard deviation. B Podocytes induced by different concentrations of serum IgG (250, 500, or 1000 μg/mL) from lupus patients for 3, 6, and 12 h. Podocyte activity was detected by CCK-8. ^*P < 0.05 vs. 0 μg/mL; ^#P < 0.05 vs. 3 h. C Expression of HOXA11-OS, Cyr61, Beclin-1, and LC3B as detected by qRT-PCR and western blotting after podocytes were induced by different concentrations of IgG from lupus patients sera for 6 h. ^*P < 0.05 vs. control group. D Expression of Cyr61, Beclin-1, and LC3B as detected by qRT-PCR and western blotting after podocytes were induced by different concentrations of IgG from normal human serum for 6 h. E Expression of HOXA11-OS mRNA in control, NC-IgG (1000 μg/mL, 6 h) and LN-IgG (1000 μg/mL, 6 h) groups was detected by qRT-PCR. ^*P < 0.01 vs. control group