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Fig. 4 | Molecular Medicine

Fig. 4

From: HOXA11-OS participates in lupus nephritis by targeting miR-124-3p mediating Cyr61 to regulate podocyte autophagy

Fig. 4

HOXA11-OS regulates autophagy factors and cell damage by targeting miR-124-3p mediating Cyr61. A The expression of Cyr61, Beclin-1, LC3B, nephrin, and podocin was detected by qRT-PCR and western blotting after transfection of miR-124-3p mimic into the ex-HOXA11-OS cell line. B The expression of Cyr61, Beclin-1, LC3B, nephrin, and podocin was detected by qRT-PCR and western blotting after transfection of miR-124-3p inhibition into the sh-HOXA11-OS#1 cell line. C, D The localization and expression of Cyr61, LC3B, and nephrin were detected by IF. *P < 0.05 vs. miR-NC; #P < 0.05 vs. ex-HOXA11-OS + miR-NC/sh-HOXA11-OS#1 + miR-NC. Data are presented as means ± standard deviation. Scale bars represent 15 µm

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Molecular Medicine

ISSN: 1528-3658