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Fig. 5 | Molecular Medicine

Fig. 5

From: HOXA11-OS participates in lupus nephritis by targeting miR-124-3p mediating Cyr61 to regulate podocyte autophagy

Fig. 5

The downregulation of Cyr61 gene can reverse the abnormal autophagy and podocyte injury induced by HOXA11-OS. A The Cyr61 gene was downregulated by knockdown lentivirus transfected into podocytes, and its expression was detected by qRT-PCR and western blotting. B The expression of HOXA11-OS, Beclin-1, LC3B, nephrin, and podocin was detected by qRT-PCR and western blotting after Cyr61 downregulation. *P < 0.05 vs. sh-NC. C The expression of Beclin-1, LC3B, nephrin, and podocin was detected by qRT-PCR and western blotting after sh-Cyr61#1 was transfected into the ex-HOXA11-OS cell line. D The localization and expression of LC3B and nephrin were detected by IF. *P < 0.05 vs. ex-NC; #P < 0.05 vs. ex-HOXA11-OS. Data are presented as means ± standard deviation. Scale bars represent 15 µm

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Molecular Medicine

ISSN: 1528-3658