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Fig. 6 | Molecular Medicine

Fig. 6

From: HOXA11-OS participates in lupus nephritis by targeting miR-124-3p mediating Cyr61 to regulate podocyte autophagy

Fig. 6

miR-124-3p inhibition leads to the deterioration of lupus mice but podocyte injury was alleviated after HOXA11-OS knockdown. Levels of 24 h urinary protein, BUN, Scr, and autoantibody in mice in each group. &P > 0.05, *P < 0.05 vs. sh-NC; #P < 0.05 vs. sh-HOXA11-OS; &*P < 0.05 vs. Lupus + sh-NC; ##P < 0.05 vs. Lupus + sh-HOXA11-OS. B,C hematoxylin–eosin and periodate-Schiff staining and histological score of kidney tissues of different groups: a sh-NC; b sh-HOXA11-OS; c miR-124-3p inhibition; d sh-HOXA11-OS + miR-124-3p inhibition; e Lupus + sh-NC; f Lupus + sh-HOXA11-OS; g Lupus + miR-124-3p inhibition; and h Lupus + sh-HOXA11-OS + miR-124-3p inhibition. Scale bars represent 20 µm. &P > 0.05, *P < 0.05 vs. sh-NC; #P < 0.05 vs. sh-HOXA11-OS; &*P < 0.05 vs. Lupus + sh-NC; ##P < 0.05 vs. Lupus + sh-HOXA11-OS

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Molecular Medicine

ISSN: 1528-3658